2024-03-20
REL
RCSB
RCSB
RCSB
2019-02-21
2018-11-21
2018-11-21
2024-03-20
Howard Hughes Medical Institute (HHMI)
United States
Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and GLPG1837
Zhang Z
Liu F
ABC transporter, anion channel, cystic fibrosis, membrane protein, GLPG1837, HYDROLASE
Liu F
Zhang Z
Levit A
Levring J
Touhara KK
Shoichet BK
Chen J
Structural identification of a hotspot on CFTR for potentiation.
Science
US
364
1184
1188
2019
31221859
doi:10.1126/science.aaw7611
1095-9203
0038
SCIEAS
6o1v
FULLOVERLAP
Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and GLPG1837
Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and GLPG1837
0
1
2
Homo sapiens
0.168
Cystic fibrosis transmembrane conductance regulator
Homo sapiens
0.169352594
1
Homo sapiens
LEVO
MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWR
FMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLI
YKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGL
GRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFL
SVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAF
WEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEG
KIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLAR
AVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDF
SSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQ
MNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQA
NLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVV
LWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAP
MSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQL
KQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISIL
TTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKK
DDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQ
QWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSV
LSKAKILLLDQPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQA
ISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRLSNSLEVLFQ
P13569
3.6.3.49
Unknown Peptide
Homo sapiens
0.0014647969999999999
1
Homo sapiens
LEVO
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)
(UNK)
N-(3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-1H-pyrazole-3-carboxamide
0.00034842
1
LJP
MAGNESIUM ION
2.4305e-05
2
MG
ADENOSINE-5'-TRIPHOSPHATE
0.000507181
2
ATP
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
0.0007600759999999999
5
POV
CHOLESTEROL
0.000386654
1
CLR
singleParticle
particle
5.5
7.5
unspecified
ETHANE
100
298
FEI VITROBOT MARK I
FEI TITAN KRIOS
FLOOD BEAM
BRIGHT FIELD
FIELD EMISSION GUN
300
GATAN K2 SUMMIT (4k x 4k)
1.51
1
510483
EMD-9230
C1
3.2
FSC 0.143 CUT-OFF
FREALIGN
510483
ANGULAR RECONSTITUTION
RELION
ANGULAR RECONSTITUTION
cisTEM
6MSM
PDB
experimental model
AB INITIO MODEL
RECIPROCAL
150.0