2023-05-31RELPDBePDBePDBe2020-06-112021-03-172021-03-172023-05-31Academy of Finland315950FinlandSigrid Juselius FoundationNAFinlandCoxsackievirus B3 in complex with capsid binder compound 17Domanska AFlatt JWButcher SJFlatt JWDomanska ASeppala ALButcher SJIdentification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses.Commun BiolUK4250250202133637854doi:10.1038/s42003-021-01779-x2399-3642EMD-11166associated EM volumeCoxsackievirus B3 in complex with capsid binder compound 176zclFULLOVERLAPCoxsackievirus B3 (strain Nancy)Coxsackievirus B3 (strain Nancy)01234Virus was grown in Vero A cells and purified in CsCl gradientCoxsackievirus B3 (strain Nancy)Nancyhumanicasaheadron300.03VIRIONSTRAINfalsefalsecapsid protein VP1Coxsackievirus B3 (strain Nancy)0.03026893capsid protein VP11LEVORVADTVGTGPTNSEAIPALTAAETGHTSQVVPGDTMQTRHVKNYHSRSESTIENFLCRSACVYFTEYKNSGAKRYAEWVL
TPRQAAQLRRKLEFFTYVRFDLELTFVITSTQQPSTTQNQDAQILTHQIMYVPPGGPVPDKVDSYVWQTSTNPSVFWTEG
NAPPRMSIPFLSIGNAYSNFYDGWSEFSRNGVYGINTLNNMGTLYARHVNAGSTGPIKSTIRIYFKPKHVKAWIPRPPRL
CQYEKAKNVNFQPSGVTTTRQSITTMTNT3.4.22.29capsid protein VP2Coxsackievirus B3 (strain Nancy)0.027604205capsid protein VP21LEVOSDRARSITLGNSTITTQECANVVVGYGVWPDYLKDSEATAEDQPTQPDVATCRFYTLDSVQWQKTSPGWWWKLPDALSNL
GLFGQNMQYHYLGRTGYTVHVQCNASKFHQGCLLVVCVPEAEMGCATLDNTPSSAELLGGDTAKEFADKPVASGSNKLVQ
RVVYNAGMGVGVGNLTIFPHQWINLRTNNSATIVMPYTNSVPMDNMFRHNNVTLMVIPFVPLDYCPGSTTYVPITVTIAP
MCAEYNGLRLAG3.4.22.29capsid protein VP3Coxsackievirus B3 (strain Nancy)0.026067596000000002capsid protein VP31LEVOGLPTMNTPGSCQFLTSDDFQSPSAMPQYDVTPEMRIPGEVKNLMEIAEVDSVVPVQNVGEKVNSMEAYQIPVRSNEGSGT
QVFGFPLQPGYSSVFSRTLLGEILNYYTHWSGSIKLTFMFCGSAMATGKFLLAYSPPGAGAPTKRVDAMLGTHVIWDVGL
QSSCVLCIPWISQTHYRFVASDEYTAGGFITCWYQTNIVVPADAQSSCYIMCFVSACNDFSVRLLKDTPFISQQNFF3.4.22.29capsid protein VP4Coxsackievirus B3 (strain Nancy)0.007449180999999999myristoylated peptide, capsid protein VP41LEVOGAQVSTQKTGAHETRLNASGNSIIHYTNINYYKDAASNSANRQDFTQDPGKFTEPVKDIMIKSLPALN3.4.22.294-[[4-[1,3-bis(oxidanylidene)isoindol-2-yl]phenyl]sulfonylamino]benzoic acid0.0004224111FHKMYRISTIC ACID0.0002283711MYRsingleParticleparticle7.5ETHANEHOMEMADE PLUNGERPurified virus was mixed with compound 17 and incubated at room temperature for 30 min before plungingFEI TITAN KRIOSFLOOD BEAMBRIGHT FIELDFIELD EMISSION GUN300GATAN K2 SUMMIT (4k x 4k)COUNTING47.012.8FSC 0.143 CUT-OFF18626MAXIMUM LIKELIHOODMAXIMUM LIKELIHOOD