2020-01-08
REL
RCSB
RCSB
RCSB
2019-04-09
2019-05-01
2019-05-08
2020-01-08
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
R01GM083118
United States
Muscarinic acetylcholine receptor 2-Go complex
Maeda S
Qianhui Q
Skiniotis G
Kobilka B
Maeda S
Qu Q
Robertson MJ
Skiniotis G
Kobilka BK
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.
Science
US
364
552
557
2019
31073061
doi:10.1126/science.aaw5188
1095-9203
0038
SCIEAS
EMD-20079
associated EM volume
GPCR complex 2
6oik
FULLOVERLAP
muscarinic acetylcholine receptor 2 in complex with heterotrimeric GoA protein
muscarinic acetylcholine receptor 2 in complex with heterotrimeric GoA protein
0
1
2
3
4
5
0.15
Muscarinic acetylcholine receptor M2
1
1
Homo sapiens
Spodoptera frugiperda
Guanine nucleotide-binding protein G(o) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Antibody fragment
1
2
3
4
5
Homo sapiens
Trichoplusia ni
Muscarinic acetylcholine receptor M2,Muscarinic acetylcholine receptor M2
Homo sapiens
0.03972991
1
Spodoptera frugiperda
LEVO
DYKDDDDASTDSSDNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVF
SMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILW
APAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSIVA
RKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYAL
CNATFKKTFKHLLMCHYKNIGATRPAGLEVLFQ
Guanine nucleotide-binding protein G(o) subunit alpha
Homo sapiens
0.040104551
1
Trichoplusia ni
LEVO
MGCTLSAEDKAAVERSKMIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQS
LAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSL
DRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDET
TNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIY
CHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens
0.037728152
1
Trichoplusia ni
LEVO
GPGSSGSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQ
DGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN
QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFF
PNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRV
SCLGVTDDGMAVATGSWDSFLKIWN
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Homo sapiens
0.007861143
1
Trichoplusia ni
LEVO
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL
Antibody fragment
Mus musculus
0.027340482
1
Trichoplusia ni
LEVO
DVQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQAPEKGLEWVAYISSGSGTIYYADTVKGRFTISRDDPKNTLF
LQMTSLRSEDTAMYYCVRSIYYYGSSPFDFWGQGTTLTVSSGGGGSGGGGSGGGGSDIVMTQATSSVPVTPGESVSISCR
SSKSLLHSNGNTYLYWFLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTISRLEAEDVGVYYCMQHLEYPLTFG
AGTKLELKGSLEVLFQ
4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium
0.000197254
1
IXO
3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide
0.000437944
1
2CU
singleParticle
particle
7.5
unspecified
ETHANE
FEI TITAN KRIOS
FLOOD BEAM
BRIGHT FIELD
FIELD EMISSION GUN
300
GATAN K2 SUMMIT (4k x 4k)
COUNTING
7.0
1
3.6
FSC 0.143 CUT-OFF
261730
ANGULAR RECONSTITUTION
ANGULAR RECONSTITUTION