2024-03-20RELRCSBRCSBRCSB2019-06-142019-09-182019-09-182024-03-20National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)GM43949United StatesHoward Hughes Medical Institute (HHMI)United StatesDamon Runyon Cancer Research FoundationDRG-2212-15United StatesSingle particle cryo-EM structure of the voltage-gated K+ channel Eag1 3-13 deletion mutant bound to calmodulin (conformation 2)Whicher JRMacKinnon RVoltage-gated potassium channel, ion channel, calmodulin, TRANSPORT PROTEIN-CALCIUM BINDING PROTEIN complexWhicher JRMacKinnon RRegulation of Eag1 gating by its intracellular domains.ElifeUS8201931490124doi:10.7554/eLife.491882050-084XEMD-20295other EM volumeSingle particle cryo-EM structure of the voltage-gated K+ channel Eag1 3-13 deletion mutant bound to calmodulin (conformation 1)6pbxFULLOVERLAPVoltage-gated potassium channel Eag1 3-13 deletion mutant bound to calmodulinVoltage-gated potassium channel Eag1 3-13 deletion mutant bound to calmodulin012Voltage-gated potassium channel Eag1 3-13 deletion mutant11Rattus norvegicuscalmodulin12Homo sapiensPotassium voltage-gated channel subfamily H member 1Rattus norvegicus0.096261434Homo sapiensLEVOMAQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSACSFMYGELTDKDTVEKVRQTFENYE
MNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPS
VQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWL
VVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRL
LRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLALDIGTPYQFNGSGSG
KWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNS
VRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQ
TVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQ
KVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGG
RDLDDLDVEKGNALTDHTSANHSLVKASVVTVRESPATPVSFYPIPEQTLQATVLEVKHELKEDIKALNAKMTSIEKQLS
EILRILMSRGSSQSPQDTCEVSRPQSPESDRDIFGASSNSLEVLFQQ63472Q63472Calmodulin-1Homo sapiens0.0168525449999999974Homo sapiensLEVOMADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDT
DSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAKP0DP23singleParticleparticle8.0unspecifiedETHANEFEI TITAN KRIOSFLOOD BEAMBRIGHT FIELDFIELD EMISSION GUN300GATAN K2 SUMMIT (4k x 4k)1.61C44.0FSC 0.143 CUT-OFFRELION354530MAXIMUM LIKELIHOODRELION3MAXIMUM LIKELIHOODRELION35K7LPDBexperimental modelFLEXIBLE FITREALemd_20294_additional_1.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
320
320320
0
00320320320320.0320.0320.090.090.090.0XYZ-0.00683111230.0299632620.0000173300210.0015176161.01.01.0Unsharpened map for Eag1 3-13/CaM conformation 2