2024-03-20RELRCSBRCSBRCSB2019-07-212019-08-282019-10-232024-03-20National Institutes of Health/National Cancer Institute (NIH/NCI)R01 CA206573United StatesCryo-EM structure of mouse TRPV3 in closed state at 42 degrees CelsiusSingh AKMcGoldrick LLIon Channels, Membrane Protein, TRP Channels, TRANSPORT PROTEINSingh AKMcGoldrick LLDemirkhanyan LLeslie MZakharian ESobolevsky AIStructural basis of temperature sensation by the TRP channel TRPV3.Nat.Struct.Mol.Biol.US26994998201931636415doi:10.1038/s41594-019-0318-71545-9985EMD-20493other EM volumeEMD-20494other EM volumeEMD-20495other EM volumeEMD-20496other EM volumeEMD-20497other EM volume6pvlFULLOVERLAPTRPV3 in closed state at 42 degree CelsiusTRPV3 in closed state at 42 degree Celsius01Mus musculusTransient receptor potential cation channel subfamily V member 3Mus musculus0.0926306954Homo sapiensLEVOMNAHSKEMAPLMGKRTTAPGGNPVVLTEKRPADLTPTKKSAHFFLEIEGFEPNPTVTKTSPPIFSKPMDSNIRQCLSGNC
DDMDSPQSPQDDVTETPSNPNSPSANLAKEEQRQKKKRLKKRIFAAVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMH
KLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGAD
VNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRM
YDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSREIKEKPLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTD
NSVLEIIVYNTNIDNRHEMLTLEPLHTLLHTKWKKFAKYMFFLSFCFYFFYNITLTLVSYYRPREDEDLPHPLALTHKMS
WLQLLGRMFVLIWATCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFVQAVLVILSVFLYLFAYKEYLACLVLAMALGWA
NMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYILFLLGFGVALASLIEKCSKDKKDCSSYGSFSDAVLELFKLTIGLG
DLNIQQNSTYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL
CKVADEDFRLCLRINEVKWTEWKTHVSFLNEDPGPIRRTADLNKIQDSSRSNSKTTLYAFDELDEFPETSVLVPRGSAAA
WSHPQFEKQ8K424SODIUM ION2.299e-052NAsingleParticleparticle4.58.0150 mM NaCl, 20 mM Tris-HCl, pH 8.0, 1 mM BME, 0.01% GDNGOLDCARBONHOLEYGLOW DISCHARGEETHANE10042FEI VITROBOT MARK IVFEI TITAN KRIOSFLOOD BEAMBRIGHT FIELDFIELD EMISSION GUN300GATAN K2 SUMMIT (4k x 4k)COUNTING57.016DVW1C44.4FSC 0.143 CUT-OFFRELION33741PROJECTION MATCHINGPROJECTION MATCHING