2020-04-22
REL
RCSB
RCSB
RCSB
2019-08-02
2019-10-02
2019-10-09
2020-04-22
National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI)
P50CA165962
United States
National Institutes of Health/National Cancer Institute (NIH/NCI)
R50CA221830
United States
Structure of a MAPK pathway complex
Park E
Rawson S
Jeon H
Eck MJ
Park E
Rawson S
Li K
Kim BW
Ficarro SB
Pino GG
Sharif H
Marto JA
Jeon H
Eck MJ
Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature
UK
575
545
550
2019
31581174
doi:10.1038/s41586-019-1660-y
1476-4687
0006
NATUAS
EMD-20552
associated EM volume
Structure of a MAPK pathway complex
6q0t
FULLOVERLAP
ERK pathway complex
ERK pathway complex
0
1
2
3
Homo sapiens
280
Serine/threonine-protein kinase B-raf
Homo sapiens
0.089306812
2
Spodoptera frugiperda
LEVO
MSYYHHHHHHHHDIPTTENLYFQGAMDMAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQM
IKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPS
SLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTD
ISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSK
FFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSAAPNVHINT
IEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIP
DGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCE
GSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL
SGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLM
AECLKKKRDERPLFPQILASIELLARSLPKIHRSA(SEP)EPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVHGTS
AWSHPQFEK
2.7.11.1
Dual specificity mitogen-activated protein kinase kinase 1
Homo sapiens
0.045835414
1
Spodoptera frugiperda
LEVO
MGSSHHHHHHSAVDENLYFQGGMPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQ
KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGE
ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDA
MANAFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS
SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCST
IGLNQPSTPTHAAG
2.7.12.2
14-3-3 protein zeta
Beet armyworm
0.028108514
2
LEVO
MSVDKEELVQRAKLAEQAERYDDMAAAMKEVTETGVELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTEGSERKQQM
AKEYRVKVEKELREICYDVLGLLDKHLIPKASNPESKVFYLKMKGDYYRYLAEVATGETRNSVVEDSQKAYQDAFEISKA
KMQPTHPIRLGLALNFSVFYYEILNSPDKACQLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDTQGDGDE
PAEGGDN
MAGNESIUM ION
2.4305e-05
1
MG
5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
0.00045621
1
LCJ
PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
0.000523247
1
AGS
singleParticle
particle
7.5
ETHANE
FEI TALOS ARCTICA
OTHER
OTHER
FIELD EMISSION GUN
200
GATAN K3 (6k x 4k)
53.0
1
5.7
FSC 0.143 CUT-OFF
595672
MAXIMUM LIKELIHOOD
MAXIMUM LIKELIHOOD
RIGID BODY FIT