2020-12-02RELRCSBRCSBRCSB2019-10-012019-10-092019-11-272020-12-02Cryo-EM structure of human CALHM2 in an active/open stateLu WDu JChoi WChoi WClemente NSun WDu JLu WThe structures and gating mechanism of human calcium homeostasis modulator 2.NatureUK576163167201931776515doi:10.1038/s41586-019-1781-31476-46870006NATUASEMD-20790other EM volumeHuman CALHM2 gap junctionEMD-20789other EM volumeHuman CALHM2 in a RUR-bound inhibited stateEMD-20788associated EM volumeHuman CALHM2 in an active/open state6uivFULLOVERLAPhuman CALHM2human CALHM201Homo sapiensHomo sapiensCalcium homeostasis modulator protein 2Homo sapiens0.03719867611Homo sapiensLEVOMAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTW
NLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARF
PCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSR
VLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMAL
LPSFESRLVPRsingleParticleparticle8unspecifiedETHANEFEI TITAN KRIOSFLOOD BEAMBRIGHT FIELDFIELD EMISSION GUN3002.71.02.5NITROGENGATAN K2 SUMMIT (4k x 4k)SUPER-RESOLUTION8.054.41576174GctfC113.3FSC 0.143 CUT-OFFRELION3.084858MAXIMUM LIKELIHOODRELION3.0MAXIMUM LIKELIHOODRELION300RELION3.0AB INITIO MODELREALemd_20788_msk_1.mapemd_20788_additional_2.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
340
340340
0
00340340340348.84348.84348.8490.090.090.0XYZ-0.0247770530.0470498280.000013716980.000465812421.0261.0261.026Map of single subunit with vertical S1. This map is obtained through symmetry expansion and signal subtraction of single subunit, followed by 3D classification.emd_20788_additional_1.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
340
340340
0
00340340340348.84348.84348.8490.090.090.0XYZ-0.00487943270.0351249950.000168170940.00167147971.0261.0261.026Map refined without a soft solvent mask. Better visualization of the highly flexible regions such as S1.