2021-04-21
REL
RCSB
RCSB
RCSB
2020-10-27
2020-11-11
2020-11-11
2021-04-21
Other private
United States
SARS-CoV-2 Spike bound to Nb11 in open conformation
Schoof MS
Faust BF
Saunders RA
Sangwan S
Rezelj V
Hoppe N
Boone M
Billesboelle CB
Puchades C
Azumaya CM
Kratochvil HT
Zimanyi M
Desphande I
Liang J
Dickinson S
Nguyen HC
Chio CM
Merz GE
Thompson MC
Diwanji D
Schaefer K
Anand AA
Dobzinski N
Zha BS
Simoneau CR
Leon K
White KM
Chio US
Gupta M
Jin M
Li F
Liu Y
Zhang K
Bulkley D
Sun M
Smith AM
Rizo AN
Moss F
Brilot AF
Pourmal S
Trenker R
Pospiech T
Gupta S
Barsi-Rhyne B
Belyy V
Barile-Hill AW
Nock S
Liu Y
Krogan NJ
Ralston CY
Swaney DL
Garcia-Sastre A
Ott M
Vignuzzi M
Walter P
Manglik A
QCRG Structural Biology Consortium
Schoof M
Faust B
Saunders RA
Sangwan S
Rezelj V
Hoppe N
Boone M
Billesbolle CB
Puchades C
Azumaya CM
Kratochvil HT
Zimanyi M
Deshpande I
Liang J
Dickinson S
Nguyen HC
Chio CM
Merz GE
Thompson MC
Diwanji D
Schaefer K
Anand AA
Dobzinski N
Zha BS
Simoneau CR
Leon K
White KM
Chio US
Gupta M
Jin M
Li F
Liu Y
Zhang K
Bulkley D
Sun M
Smith AM
Rizo AN
Moss F
Brilot AF
Pourmal S
Trenker R
Pospiech T
Gupta S
Barsi-Rhyne B
Belyy V
Barile-Hill AW
Nock S
Liu Y
Krogan NJ
Ralston CY
Swaney DL
Garcia-Sastre A
Ott M
Vignuzzi M
QCRG Structural Biology Consortium
Walter P
Manglik A
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science
US
370
1473
1479
2020
33154106
doi:10.1126/science.abe3255
1095-9203
0038
SCIEAS
EMD-22911
associated EM volume
EMD-22907
other EM volume
EMD-22909
other EM volume
EMD-22908
other EM volume
EMD-22910
other EM volume
Complex of Spike S2P glycoprotein with synthetic nanobody Nb11
Complex of Spike S2P glycoprotein with synthetic nanobody Nb11
0
Spike S2P glycoprotein
1
Severe acute respiratory syndrome coronavirus 2
Cricetulus griseus
ExpiCHO
synthetic nanobody Nb11
1
synthetic construct
Escherichia coli BL21(DE3)
singleParticle
particle
8.0
Quantifoil
GOLD
300
CARBON
HOLEY
GLOW DISCHARGE
ETHANE
100
FEI VITROBOT MARK IV
FEI TITAN KRIOS
FLOOD BEAM
BRIGHT FIELD
FIELD EMISSION GUN
300
105000.0
FEI TITAN KRIOS AUTOGRID HOLDER
GIF Bioquantum
20
GATAN K3 BIOQUANTUM (6k x 4k)
4103
66.0
1
1204855
cryoSPARC
2.15.0
Performed at reconstruction, as is standard for cryoSPARC
C1
3.74
FSC 0.143 CUT-OFF
RELION
3.1.0
21570
MAXIMUM LIKELIHOOD
cryoSPARC
2.15.0
MAXIMUM LIKELIHOOD
RELION
3.1.0