2024-03-06RELRCSBRCSBRCSB2020-12-102021-02-242021-02-242024-03-06National Institutes of Health/Office of the DirectorUnited StatesHigh resolution cryo EM analysis of HPV16 identifies minor structural protein L2 and describes capsid flexibilityHartmann SRGoetschius DJHPV16, quasivirus, L1, capsomer, subparticle, VIRUSGoetschius DJHartmann SRSubramanian SBator CMChristensen NDHafenstein SLHigh resolution cryo EM analysis of HPV16 identifies minor structural protein L2 and describes capsid flexibility.Sci RepUK1134983498202133568731doi:10.1038/s41598-021-83076-52045-23227kzfFULLOVERLAPHuman papillomavirus type 16Human papillomavirus type 1601Human papillomavirus type 16VIRUS-LIKE PARTICLESTRAINfalsefalseMajor capsid protein L1Human papillomavirus type 160.0560986169999999966Homo sapiensLEVOMSLWLPSEATVYLPPVPVSKVVSTDEYVARTNIYYHAGTSRLLAVGHPYFPIKKPNNNKILVPKVSGLQYRVFRIHLPDP
NKFGFPDTSFYNPDTQRLVWACVGVEVGRGQPLGVGISGHPLLNKLDDTENASAYAANAGVDNRECISMDYKQTQLCLIG
CKPPIGEHWGKGSPCTNVAVNPGDCPPLELINTVIQDGDMVDTGFGAMDFTTLQANKSEVPLDICTSICKYPDYIKMVSE
PYGDSLFFYLRREQMFVRHLFNRAGAVGENVPDDLYIKGSGSTANLASSNYFPTPSGSMVTSDAQIFNKPYWLQRAQGHN
NGICWGNQLFVTVVDTTRSTNMSLCAAISTSETTYKNTNFKEYLRHGEEYDLQFIFQLCKITLTADVMTYIHSMNSTILE
DWNFGLQPPPGGTLEDTYRFVTSQAIACQKHTPPAPKEDPLKKYTFWEVNLKEKFSADLDQFPLGRKFLLQAGLKAKPKF
TLGKRKATPTTSSTSTTAKRKKRP03101singleParticleparticle7.41.0PBSGLOW DISCHARGEunspecifiedETHANE100277FEI VITROBOT MARK IVFEI TITAN KRIOSFLOOD BEAMBRIGHT FIELDFIELD EMISSION GUN3000.01NITROGENFEI FALCON III (4k x 4k)COUNTING11014360.012027053.1FSC 0.143 CUT-OFF181299MAXIMUM LIKELIHOODOTHERemd_23081_additional_1.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
300
300300
-150
-150-150300300300330.0330.0330.090.090.090.0XYZ-17.11895226.1591740.0000000064337510.999999941.11.11.1HPV16 quasivirus pentavalent capsomer subvolume refinement.emd_23081_additional_3.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
700
700700
-350
-350-350700700700770.0770.0770.090.090.090.0XYZ-0.80608282.331575-0.0009860.167290841.11.11.1HPV16 quasivirus icosahedral refinement from which pentavalent and hexavalent subvolumes were extracted.emd_23081_additional_2.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)