2021-06-09
REL
RCSB
RCSB
RCSB
2020-12-10
2020-12-30
2020-12-30
2021-06-09
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
AI145687
United States
Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to one copy of domain-swapped antibody 2G12
Manne K
Henderson R
Acharya P
Williams WB
Meyerhoff RR
Edwards RJ
Li H
Manne K
Nicely NI
Henderson R
Zhou Y
Janowska K
Mansouri K
Gobeil S
Evangelous T
Hora B
Berry M
Abuahmad AY
Sprenz J
Deyton M
Stalls V
Kopp M
Hsu AL
Borgnia MJ
Stewart-Jones GBE
Lee MS
Bronkema N
Moody MA
Wiehe K
Bradley T
Alam SM
Parks RJ
Foulger A
Oguin T
Sempowski GD
Bonsignori M
LaBranche CC
Montefiori DC
Seaman M
Santra S
Perfect J
Francica JR
Lynn GM
Aussedat B
Walkowicz WE
Laga R
Kelsoe G
Saunders KO
Fera D
Kwong PD
Seder RA
Bartesaghi A
Shaw GM
Acharya P
Haynes BF
Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.
Cell
184
2955
2021
34019795
doi:10.1016/j.cell.2021.04.042
1097-4172
Acharya P
Williams W
Henderson R
Janowska K
Manne K
Parks R
Deyton M
Sprenz J
Stalls V
Kopp M
Mansouri K
Edwards RJ
Meyerhoff RR
Oguin T
Sempowski G
Saunders K
Haynes BF
A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies.
Biorxiv
US
2020
32637953
doi:10.1101/2020.06.30.178897
EMD-23094
associated EM volume
EMD-23095
other EM volume
EMD-23097
other EM volume
7l02
FULLOVERLAP
Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2G12
Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2G12
0
1
2
3
Severe acute respiratory syndrome-related coronavirus
spike glycoprotein
1
1
Severe acute respiratory syndrome coronavirus 2
Homo sapiens
antibody 2G12
1
2
3
Homo sapiens
Spike glycoprotein
Severe acute respiratory syndrome coronavirus 2
0.124124477
3
Homo sapiens
LEVO
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIF
GTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNF
KNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYY
VGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATR
FASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLP
DDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQ
PYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILD
ITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPI
GAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDS
TECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKV
TLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRF
NGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDP
PEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVT
YVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELD
S
2G12 heavy chain
Homo sapiens
0.023978050999999997
2
Homo sapiens
LEVO
EVQLVESGGGLVKAGGSLILSCGVSNFRISAHTMNWVRRVPGGGLEWVASISTSSTYRDYADAVKGRFTVSRDDLEDFVY
LQMHKMRVEDTAIYYCARKGSDRLSDNDPFDAWGPGTVVTVSPASTKGPSVFPLAPS(UNK)(UNK)(UNK)(UNK)
(UNK)(UNK)(UNK)(UNK)GTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQT
YICNVNHKPSNTKVDKKVEPK
2G12 light chain
Homo sapiens
0.02324585
2
Homo sapiens
LEVO
DVVMTQSPSTLSASVGDTITITCRASQSIETWLAWYQQKPGKAPKLLIYKASTLKTGVPSRFSGSGSGTEFTLTISGLQF
DDFATYHCQHYAGYSATFGQGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
2-acetamido-2-deoxy-beta-D-glucopyranose
0.000221208
31
NAG
singleParticle
particle
7.4
Quantifoil R1.2/1.3
COPPER
300
CARBON
HOLEY
GLOW DISCHARGE
ETHANE
FEI TITAN KRIOS
FLOOD BEAM
BRIGHT FIELD
FIELD EMISSION GUN
300
FEI TITAN KRIOS AUTOGRID HOLDER
NITROGEN
97.0
97.0
GATAN K3 (6k x 4k)
66.43
1
cryoSPARC
6VXX
C1
3.2
FSC 0.143 CUT-OFF
cryoSPARC
107551
MAXIMUM LIKELIHOOD
cryoSPARC
MAXIMUM LIKELIHOOD
cryoSPARC
cryoSPARC
6VXX
AB INITIO MODEL