2021-09-15RELRCSBRCSBRCSB2021-02-062021-09-152021-09-152021-09-15Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 3)Pan MYu YLiu LZhao MPan MYu YAi HZheng QXie YLiu LZhao MMechanistic insight into substrate processing and allosteric inhibition of human p97.Nat.Struct.Mol.Biol.US28614625202134262183doi:10.1038/s41594-021-00617-21545-9985EMD-23442other EM volumeEMD-23443other EM volumeEMD-23444other EM volumeEMD-23445associated EM volumeEMD-23446other EM volumeEMD-23447other EM volumeEMD-23448other EM volumeEMD-23449other EM volumeEMD-23450other EM volumeEMD-23451other EM volumeEMD-23452other EM volumeEMD-23453other EM volumeEMD-23454other EM volumeEMD-23455other EM volumeEMD-23456other EM volumeEMD-23457other EM volumeEMD-23458other EM volume7ln1FULLOVERLAPHuman p97 in complex with Npl4/Ufd1 and K48-linked Ub6 in the presence of ATPHuman p97 in complex with Npl4/Ufd1 and K48-linked Ub6 in the presence of ATP012Homo sapiensEscherichia coli K-12Transitional endoplasmic reticulum ATPaseHomo sapiens0.0894938526Escherichia coliLEVOMASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDE
KIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRA
VEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKEIGVKPPRG
ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEV
ERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVA
NETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIG
GLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVR
EIFDKARQAAPCVLFFDQLDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLD
QLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAM
EVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGAGPSQGSGGGTGGSVYTEDN
DDDLYG3.6.4.6Hexa-ubiquitinHomo sapiens0.0007839581Escherichia coliLEVO(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)ADENOSINE-5'-DIPHOSPHATE0.0004272015ADPADENOSINE-5'-TRIPHOSPHATE0.0005071817ATPMAGNESIUM ION2.4305e-057MGsingleParticleparticle2.58.0ETHANE100281FEI TITAN KRIOSFLOOD BEAMBRIGHT FIELDFIELD EMISSION GUN30070.0GATAN K3 BIOQUANTUM (6k x 4k)50.017JY5C13.4FSC 0.143 CUT-OFFRELION3.198051RANDOM ASSIGNMENTRELION3.1MAXIMUM LIKELIHOODRELION3.1AB INITIO MODELREALemd_23445_msk_1.mapemd_23445_additional_1.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
320
320320
0
00320320320340.15997340.15997340.1599790.090.090.0XYZ-0.08372460.18659586-6.14354e-050.0047395411.0631.0631.063emd_23445_half_map_2.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
320
320320
0
00320320320340.15997340.15997340.1599790.090.090.0XYZ-0.0356614180.09956631-6.0330432e-050.00363610571.0631.0631.063emd_23445_half_map_1.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)