2021-09-15RELRCSBRCSBRCSB2021-02-062021-09-152021-09-152021-09-15Human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos in the presence of ATP and sub-stoichiometric NMS-873 (Class 2)Pan MYu YLiu LZhao MPan MYu YAi HZheng QXie YLiu LZhao MMechanistic insight into substrate processing and allosteric inhibition of human p97.Nat.Struct.Mol.Biol.US28614625202134262183doi:10.1038/s41594-021-00617-21545-9985EMD-23442other EM volumeEMD-23443other EM volumeEMD-23444other EM volumeEMD-23445other EM volumeEMD-23446other EM volumeEMD-23447other EM volumeEMD-23448other EM volumeEMD-23449other EM volumeEMD-23450other EM volumeEMD-23451other EM volumeEMD-23452other EM volumeEMD-23453other EM volumeEMD-23454associated EM volumeEMD-23455other EM volumeEMD-23456other EM volumeEMD-23457other EM volumeEMD-23458other EM volumeHuman p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos in the presence of ATP and sub-stoichiometric NMS-873Human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos in the presence of ATP and sub-stoichiometric NMS-87301Homo sapiensEscherichia coli K-12Human p97 (A232E/E578Q)Homo sapiensEscherichia coli K-12LEVOMASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLK
GKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPID
DTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDT
VIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKEIGVKPPRG
ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI
IFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRF
GRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAAL
QAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIG
GLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFI
SIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDQLDSIAKARGGNIGDGGGAADRV
INQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKAN
LRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAM
EVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGG
AGPSQGSGGGTGGSVYTEDNDDDLYGsingleParticleparticle2.58.0ETHANE100281FEI TITAN KRIOSFLOOD BEAMBRIGHT FIELDFIELD EMISSION GUN30070.0GATAN K3 BIOQUANTUM (6k x 4k)50.017JY5C16.0FSC 0.143 CUT-OFFRELION3.129966RANDOM ASSIGNMENTRELION3.1MAXIMUM LIKELIHOODRELION3.1AB INITIO MODELREALemd_23454_msk_1.mapemd_23454_additional_1.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
320
320320
0
00320320320340.15997340.15997340.1599790.090.090.0XYZ-0.0180985090.05144076-7.6454424e-050.0028540761.0631.0631.063emd_23454_half_map_2.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
320
320320
0
00320320320340.15997340.15997340.1599790.090.090.0XYZ-0.0313746040.055346455-7.63244e-050.00366978461.0631.0631.063emd_23454_half_map_1.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)