2022-01-05
REL
RCSB
RCSB
RCSB
2021-04-08
2022-01-05
2022-01-05
2022-01-05
Structure of the autoinhibited state of smooth muscle myosin-2
Heissler SM
Arora AS
Billington N
Sellers JR
Chinthalapudi K
Heissler SM
Arora AS
Billington N
Sellers JR
Chinthalapudi K
Cryo-EM structure of the autoinhibited state of myosin-2.
Sci Adv
US
7
eabk3273
eabk3273
2021
34936462
doi:10.1126/sciadv.abk3273
2375-2548
EMD-23810
associated EM volume
Structure of the autoinhibited state of smooth muscle myosin-2
7mf3
FULLOVERLAP
Smooth muscle myosin-2 10S complex
Smooth muscle myosin-2 10S complex
0
1
2
3
Gallus gallus
Gizzard
0.531256
Myosin-11
Chicken
gizzard
0.229018953
4
LEVO
SQKPLSDDEKFLFVDKNFVNNPLAQADWSAKKLVWVPSEKHGFEAASIKEEKGDEVTVELQENGKKVTLSKDDIQKMNPP
KFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVINPYKQLPIYSEKIIDMYKGKKRHEMPPHIYAIADTAY
RSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFSYGELEKQLLQANPILEAFGNAKTVK
NDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAKDERTFHIFYYLIAGASEQMRNDLLLEGFNNYTFLSNGHV
PIPAQQDDEMFQETLEAMTIMGFTEEEQTSILRVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRS
ILTPRIKVGRDVVQKAQTKEQADFAIEALAKAKFERLFRWILTRVNKALDKTKRQGASFLGILDIAGFEIFEINSFEQLC
INYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPTNPPGVLALLDEECWFPKATDTSFVEKLIQ
EQGNHAKFQKSKQLKDKTEFCILHYAGKVTYNASAWLTKNMDPLNDNVTSLLNQSSDKFVADLWKDVDRIVGLDQMAKMT
ESSLPSASKTKKGMFRTVGQLYKEQLTKLMTTLRNTNPNFVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQGF
PNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIIAFQA
QCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKDEELQRTKERQQKAEAEL
KELEQKHTQLCEEKNLLQEKLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARIEEEEERSQQLQAEKKKMQQQMLDL
EEQLEEEEAARQKLQLEKVTADGKIKKMEDDILIMEDQNNKLTKERKLLEERVSDLTTNLAEEEEKAKNLTKLKNKHESM
ISELEVRLKKEEKSRQELEKIKRKLEGESSDLHEQIAELQAQIAELKAQLAKKEEELQAALARLEDETSQKNNALKKIRE
LESHISDLQEDLESEKAARNKAEKQKRDLSEELEALKTELEDTLDTTATQQELRAKREQEVTVLKRALEEETRTHEAQVQ
EMRQKHTQAVEELTEQLEQFKRAKANLDKTKQTLEKDNADLANEIRSLSQAKQDVEHKKKKLEVQLQDLQSKYSDGERVR
TELNEKVHKLQIEVENVTSLLNEAESKNIKLTKDVATLGSQLQDTQELLQEETRQKLNVTTKLRQLEDDKNSLQEQLDEE
VEAKQNLERHISTLTIQLSDSKKKLQEFTATVETMEEGKKKLQREIESLTQQFEEKAASYDKLEKTKNRLQQELDDLVVD
LDNQRQLVSNLEKKQKKFDQMLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED
LVSSKDDVGKNVHELEKSKRTLEQQVEEMKTQLEELEDELQAAEDAKLRLEVNMQAMKSQFERDLQARDEQNEEKRRQLL
KQLHEHETELEDERKQRALAAAAKKKLEVDVKDLESQVDSANKAREEAIKQLRKLQAQMKDYQRDLDDARAAREEIFATA
RENEKKAKNLEAELIQLQEDLAAAERARKQADLEKEEMAEELASANSGRTSLQDEKRRLEARIAQLEEELDEEHSNIETM
SDRMRKAVQQAEQLNNELATERATAQKNENARQQLERQNKELRSKLQEMEGAVKSKFKSTIAALEAKIASLEEQLEQEAR
EKQAAAKTLRQKDKKLKDALLQVEDERKQAEQYKDQAEKGNLRLKQLKRQLEEAEEESQRINANRRKLQRELDEATESND
ALGREVAALKSKLRRGNEPVSFAPPRRSGGRRVIENATDGGEEEIDGRDGDFNGKASE
Myosin light polypeptide 6
Chicken
Gizzard
0.016873025
2
LEVO
CDFSEEQTAEFKEAFQLFDRTGDGKILYSQCGDVMRALGQNPTNAEVMKVLGNPKSDEMNLKTLKFEQFLPMMQTIAKNK
DQGCFEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEQLVAGHEDSNGCINYEELVRMVLSG
Myosin regulatory light chain 2, smooth muscle major isoform
Chicken
Gizzard
0.019741046999999998
2
LEVO
SSKRAKAKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASMGKNPTDEYLEGMMSEAPGPI
NFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEASGFIHEDHLRELLTTMGDRFTDEEVDEMYREAPIDKKGNFNYVEFTR
ILKHGAKDKDD
ADENOSINE-5'-DIPHOSPHATE
0.000427201
2
ADP
PHOSPHATE ION
9.4971e-05
2
PO4
MAGNESIUM ION
2.4305e-05
4
MG
singleParticle
tissue
7.3
150.0
NaCl
sodium chloride
150 mM NaCl, 1mM EGTA, 2mM MgCl2
C-flat-1.2/1.3
GOLD
300
CARBON
HOLEY
GLOW DISCHARGE
AIR
ETHANE
95
292
LEICA EM GP
1 mg/ml
FEI TITAN KRIOS
OTHER
BRIGHT FIELD
FIELD EMISSION GUN
300
0.01
81000.0
FEI TITAN KRIOS AUTOGRID HOLDER
GIF Bioquantum
20
GATAN K3 BIOQUANTUM (6k x 4k)
1
65.0
1
Gctf
1BR2
1
C1
3.4
FSC 0.143 CUT-OFF
cryoSPARC
234464
OTHER
cryoSPARC
OTHER
cryoSPARC
5I4E
A
FLEXIBLE FIT
REAL