2022-12-21RELRCSBRCSBRCSB2021-12-012022-11-232022-11-232022-12-21National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)United StatesZika Virus particle bound with IgM antibody DH1017 Fab fragmentMiller ASKuhn RJSingh THwang KKMiller ASJones RLLopez CADulson SJGiuberti CGladden MAMiller IWebster HSEudailey JALuo KVon Holle TEdwards RJValencia SBurgomaster KEZhang SMangold JFTu JJDennis MAlam SMPremkumar LDietze RPierson TCOoi EELazear HMKuhn RJPermar SRBonsignori MA Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization.Cell18548264840.e17202236402135doi:10.1016/j.cell.2022.10.0231097-4172EMD-25606associated EM volumeZika Virus asymmetric unit bound with IgM antibody DH1017 Fab fragment7t17FULLOVERLAPZika virusZika virus012345Zika virusVIRIONSTRAINtruefalseDH1017.IgM FabC constant domainHomo sapiens0.0108301881Homo sapiensLEVOASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQT
YICNVNHKPSNTKVDKKVEPKSCDKDH1017.IgM LambdaC constant domainHomo sapiens0.011361571Homo sapiensLEVOGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWK
SHRSYSCQVTHEGSTVEKTVAPTECSDH1017.IgM IgHHomo sapiens0.0133258162Homo sapiensLEVOQVQLQESGPGLVKPSQTLSLTCAVSGGSISSGDSYWSWIRQHPGKGLEWIGSIYYSGSTYYNPSLKSRVTIPIDTSKNQF
SLKLSSVTAADTAVYYCARHVGDLRVNDAFDIWGQGTMVTVSSDH1017.IgM IgLHomo sapiens0.011482752Homo sapiensLEVOQSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNFVSWYQRLPGTPPKLLIYDSDKRPSGIPDRFSGSKSGTSATLGITGLQ
TGDEGDYYCGTWDRSLSVVVFGGGTKLTVLCore proteinZika virus0.0426232773LEVOIRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPTVDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEA
YLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTCAKFACSKKMTGKSIQPENLEYRIMLSVHGSQHSGMIVNDTGHET
DENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSDLYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKE
ALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGAKGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAE
TLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVG3.4.21.91singleParticleparticle8.0ETHANEFEI TITAN KRIOSFLOOD BEAMBRIGHT FIELDFIELD EMISSION GUN300GATAN K3 (6k x 4k)35.015.26FSC 0.143 CUT-OFF4104RANDOM ASSIGNMENTPROJECTION MATCHINGemd_25606_half_map_1.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
1024
10241024
-520
-520-5201024102410241331.21331.21331.290.090.090.0XYZ-4.7549598.1332950.0057910120.29004151.321.321.32emd_25606_half_map_2.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)