2023-07-05RELRCSBRCSBRCSB2022-07-202023-03-082023-03-082023-07-05National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)F32GM128263United StatesLRRC8A:C conformation 2 (oblong)Kern DMBrohawn SGION CHANNEL, VOLUME-REGULATION, MEMBRANE PROTEINKern DMBleier JMukherjee SHill JMKossiakoff AAIsacoff EYBrohawn SGStructural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.Nat.Struct.Mol.Biol.US30841852202336928458doi:10.1038/s41594-023-00944-61545-9985EMD-27675other EM volumeLRR masked mapEMD-27674other EM volumeTop masked mapEMD-27676associated EM volumeLRRC8A:C conformation 2 (oblong)8dreFULLOVERLAPLRRC8A:CLRRC8A:C012Mus musculus0.620Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562Mus musculus0.1055301025Spodoptera frugiperdaLEVOMIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWVTKDSCNDSFRGWAASSADLE
DNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKV
KEAQAAAEQLKTTRNAYIQKYLDTGPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPR
TSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSE
TGVLDKKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFALIICYTVYYVHNIKFDVDCTVDIESLTGYRTY
RCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSK
RFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQL
TGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKV
LRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKT
IEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQ
NLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEE
DLFSTLPPEVKERLWRADKEQASNSLEVLFQVolume-regulated anion channel subunit LRRC8CMus musculus0.093624593999999991Spodoptera frugiperdaLEVOMIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSVPNVSQAVISTTP
LPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS
ILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNRSGTIQSGPEGNLVRSQSLKSIPEKFVVDKSAAGALDKKEGEQAKA
LFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLS
FCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKL
KQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQCSVK
IHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQAV
VDVSSHLQKMCVHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLT
VLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVES
LPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDIKGNHFEVLPPELGDCRALKRAGLVVEDALFETLPSDVREQM
KADSNSENLYFQG1,2-dioleoyl-sn-glycero-3-phosphoethanolamine0.00074403420PEEwater1.8015e-056HOHsingleParticleparticle27.4ETHANETFS KRIOSFLOOD BEAMBRIGHT FIELDFIELD EMISSION GUN3000.62.0GATAN K3 BIOQUANTUM (6k x 4k)50.013.18FSC 0.143 CUT-OFF126955MAXIMUM LIKELIHOODMAXIMUM LIKELIHOODemd_27676_additional_2.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
416
416416
0
00416416416435.968435.968435.96890.090.090.0XYZ-2.27491074.30512240.00146026480.0619376041.0481.0481.048Sharpened global refinement mapemd_27676_additional_1.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
416
416416
0
00416416416435.968435.968435.96890.090.090.0XYZ-0.717345362.12402340.00146026490.0395723661.0481.0481.048Unsharpened global refinement mapemd_27676_half_map_2.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
416
416416
0
00416416416435.968435.968435.96890.090.090.0XYZ-1.12671822.38461730.00197135660.08374461.0481.0481.048Half Map 2emd_27676_half_map_1.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)