2024-03-27
REL
PDBj
PDBj
PDBj
2020-09-23
2020-11-11
2020-11-11
2024-03-27
Structure of COVID-19 RNA-dependent RNA polymerase bound to suramin
Li Z
Yin W
COVID-19, RNA polymerase, suramin binding, VIRAL PROTEIN
Yin W
Luan X
Li Z
Zhou Z
Wang Q
Gao M
Wang X
Zhou F
Shi J
You E
Liu M
Wang Q
Jiang Y
Jiang H
Xiao G
Zhang L
Yu X
Zhang S
Eric Xu H
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin.
Nat.Struct.Mol.Biol.
US
28
319
325
2021
33674802
doi:10.1038/s41594-021-00570-0
1545-9985
7d4f
FULLOVERLAP
COVID-19 RdRp complex bound to suramin
COVID-19 RdRp complex bound to suramin
0
1
2
3
Severe acute respiratory syndrome coronavirus 2
Non-structural protein 8
Severe acute respiratory syndrome coronavirus 2
0.022034242
2
Spodoptera frugiperda
LEVO
MAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDK
RAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQV
VDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQ
P0DTD1
Non-structural protein 7
Severe acute respiratory syndrome coronavirus 2
0.00938
1
Spodoptera frugiperda
LEVO
MSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNR
ATLQ
P0DTD1
RNA-directed RNA polymerase
Severe acute respiratory syndrome coronavirus 2
0.10796525
1
Spodoptera frugiperda
LEVO
MSADAQSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSN
YQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNK
KDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYS
LLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFST
VFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVA
ALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKY
FDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAG
VSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLA
RKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKY
VRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKC
WTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYAD
VFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQGGSENLYFQG
P0DTD1
2.7.7.48
ZINC ION
6.5409e-05
2
ZN
8-(3-(3-aminobenzamido)-4-methylbenzamido)naphthalene-1,3,5-trisulfonic acid
0.000635643
2
H3U
singleParticle
particle
7.4
ETHANE
FEI TITAN KRIOS
FLOOD BEAM
BRIGHT FIELD
FIELD EMISSION GUN
300
GATAN K3 BIOQUANTUM (6k x 4k)
68.0
1
2.57
FSC 0.143 CUT-OFF
95845
MAXIMUM LIKELIHOOD
MAXIMUM LIKELIHOOD