2021-06-16RELPDBjPDBjPDBj2021-01-182021-03-312021-03-312021-06-16National Natural Science Foundation of China (NSFC)31971123ChinaNational Natural Science Foundation of China (NSFC)81920108015ChinaNational Natural Science Foundation of China (NSFC)31930059ChinaS protein of SARS-CoV-2 in the active conformationYan RHZhang YYLi YNYe FFGuo YYXia LZhong XYChi XMZhou QYan RZhang YLi YYe FGuo YXia LZhong XChi XZhou QStructural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2.Cell Res.CN31717719202133737693doi:10.1038/s41422-021-00490-01001-0602EMD-30890associated EM volumeS protein of SARS-CoV-2 in the active conformation7dwzFULLOVERLAPS protein of SARS-CoV-2 in the active conformationS protein of SARS-CoV-2 in the active conformation01Severe acute respiratory syndrome coronavirus 2Homo sapiensSpike glycoproteinSevere acute respiratory syndrome coronavirus 20.1425025943Homo sapiensLEVOMFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFD
NPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVY
SSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQT
LLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRV
QPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSF
VIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPC
NGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFL
PFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGS
NVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTI
SVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGF
NFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAG
TITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALN
TLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRV
DFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNT
FVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDL
QELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYTLEDYKDD
DDK2-acetamido-2-deoxy-beta-D-glucopyranose0.00022120827NAGsingleParticleparticle8.0ETHANEFEI TITAN KRIOSFLOOD BEAMBRIGHT FIELDFIELD EMISSION GUN300FEI TITAN KRIOS AUTOGRID HOLDERNITROGENGATAN K3 BIOQUANTUM (6k x 4k)50.013.3FSC 0.143 CUT-OFFRELION3.0.664122ANGULAR RECONSTITUTIONMAXIMUM LIKELIHOOD