2022-11-30
REL
PDBj
PDBj
PDBj
2022-01-22
2022-11-30
2022-11-30
2022-11-30
National Natural Science Foundation of China (NSFC)
81900729
China
The state 4 of Omicron Spike with bispecific antibody FD01
Zhang X
Zhan WQ
Chen ZG
Sun L
Wang Y
Zhang X
Ma Y
Wang Y
Zhan W
Zheng Q
Zhang M
Ji P
Liu M
Liu Q
Sun T
Zhu T
Wen Y
Sun L
Zhao J
Wu F
Chen Z
Huang J
Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies
Cell Discov
UK
8
104
2022
36207299
doi:10.1038/s41421-022-00463-6
2056-5968
EMD-32659
associated EM volume
Omicron S-B13 state 4
7wou
FULLOVERLAP
Omicron Spike with 16L9 and GW01
Omicron Spike with 16L9 and GW01
0
1
2
3
Omicron Spike
1
1
Severe acute respiratory syndrome coronavirus 2
16L9 and GW01
1
2
3
Homo sapiens
Spike glycoprotein
Severe acute respiratory syndrome coronavirus 2
0.142506
residues 682-685 are substitution at furin cleavage site. T4 fibritin trimerization motif, twin strep II tag and 8-His were introduced at C-terminal.
3
Homo sapiens
LEVO
MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHVISGTNGTKRFDNP
VLPFNDGVYFASIEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLDHKNNKSWMESEFRVYSSANN
CTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPIIVREPEDLPQGFSALEPLVDLPIGINITRFQTLLA
LHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPT
ESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNLAPFFTFKCYGVSPTKLNDLCFTNVYADSFVIR
GDEVRQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVSGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGV
AGFNCYFPLRSYSFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLKGTGVLTESNKKFLPFQ
QFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTGSNVF
QTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKSHGSASSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVT
TEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFS
QILPDPSKPSKRSPIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFKGLTVLPPLLTDEMIAQYTSALLAGTIT
SGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNHNAQALNTLV
KQLSSKFGAISSVLNDIFSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFC
GKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVS
GNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL
GKYEQGSGYIPEAPRDGQAYVRKDGEWVFLSTFLSGLEVLFQGPGGWSHPQFEKGGGSGGGSGGSAWSHPQFEKGGSHHH
HHHHH
16L9 Fv
Homo sapiens
0.025730025
2
Homo sapiens
LEVO
QSVLTQPPSASGSPGQSVTISCTGTSSDFGGYNSVSWYQQHPGKAPKLMIYEVSKRPSGVPDRFSGSKSGNTASLTVSGL
QAEDEADYYCSSYAGSNNFDVFGTGTKVTVLGGGGSGGGGSGGGGSEVQLVESGGGLIQPGGSLRLSCAASGFTVSSNYM
SWVRQAPGKGLEWVSVIYSGGSTYYADSVKGRFTISRDNSENTLYLQMNSLRAEDTAVYYCARGEIQPYYYYGMDVWGQG
TTVTVSS
GW01 Fv
Homo sapiens
0.026186488
2
Homo sapiens
LEVO
QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNWYQQLPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQ
SEDEADYYCAAWDDSLNWVFGGGTKLTVLGGGGSGGGGSGGGGSEVQLVESGGGVVQPGGSLRLSCAASGFRFDDHAMHW
VRQAPGKGLEWVSVISGDGGSTYYADSVKGRFSISRDDSKNSLYLQMNSLRTEDTALYYCAKDRSYGPPDVFNYEYGMDV
WGQGTTVTVSS
2-acetamido-2-deoxy-beta-D-glucopyranose
0.000221208
23
NAG
singleParticle
particle
8.0
ETHANE
FEI TITAN KRIOS
FLOOD BEAM
BRIGHT FIELD
FIELD EMISSION GUN
300
1.2
2.5
GATAN K3 BIOQUANTUM (6k x 4k)
58.0
1
3.47
FSC 0.143 CUT-OFF
141577
PROJECTION MATCHING
PROJECTION MATCHING