2023-01-25RELPDBjPDBjPDBj2022-04-302022-11-302022-11-302023-01-25National Natural Science Foundation of China (NSFC)32170683ChinaNational Natural Science Foundation of China (NSFC)82188101ChinaNational Natural Science Foundation of China (NSFC)31872716ChinaNational Natural Science Foundation of China (NSFC)82171421ChinaNational Natural Science Foundation of China (NSFC)91949118ChinaNational Natural Science Foundation of China (NSFC)81771372ChinaNational Natural Science Foundation of China (NSFC)U1932204ChinaMinor polymorph inalpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-1) Parkinson's disease patientFan YSun YPWang JLiu CFan YSun YYu WTao YXia WLiu YZhao QTang YSun YLiu FCao QWu JLiu CWang JLi DConformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.StructureUK3178202336513068doi:10.1016/j.str.2022.11.0130969-21262005STRUE6EMD-33332associated EM volumeType 3A alpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-1) Parkinson's disease patient7xo0FULLOVERLAPMinor polymorph inalpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-1) Parkinson's disease patientMinor polymorph inalpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-1) Parkinson's disease patient01Homo sapiensAlpha-synucleinHomo sapiens0.0144761086Escherichia coliLEVOMDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQK
TVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEAhelicalfilament6.5ETHANEFEI TITAN KRIOSFLOOD BEAMBRIGHT FIELDFIELD EMISSION GUN3001.02.0GATAN K3 (6k x 4k)55.012.42179.34C13.0FSC 0.143 CUT-OFF368236SSXNOT APPLICABLEemd_33332_half_map_2.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
288
288288
0
00288288288305.27997305.27997305.2799790.090.090.0XYZ-0.00849593150.028507140.000324897320.00186099861.061.061.06emd_33332_half_map_1.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)