2024-03-13
REL
RCSB
RCSB
RCSB
2018-08-20
2018-02-28
2018-11-21
2024-03-13
Mycobacterium tuberculosis RNAP with RbpA/us fork and Corallopyronin
Darst SA
Campbell EA
initiation, transcription bubble, closed clamp, open promoter complex, TRANSCRIPTION, TRANSCRIPTION-DNA complex
Boyaci H
Chen J
Jansen R
Darst SA
Campbell EA
Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature
UK
565
382
385
2019
30626968
doi:10.1038/s41586-018-0840-5
1476-4687
0006
NATUAS
EMD-9039
other EM volume
EMD-9041
other EM volume
EMD-9037
other EM volume
6m7j
FULLOVERLAP
Mycobacterium tuberculosis RNAP open promoter complex
Mycobacterium tuberculosis RNAP open promoter complex
0
1
2
3
4
5
6
7
8
Mycobacterium tuberculosis
DNA-directed RNA polymerase subunit alpha
Mycobacterium tuberculosis
0.037745328
2
Escherichia coli
LEVO
MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNL
KSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHNPGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIG
RIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKNSISPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAE
ADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIKLHQLGLSLKDSPPSFDPSEV
AGYDVATGTWSTEGAYDEQDYAETEQL
A5U8D3
2.7.7.6
DNA-directed RNA polymerase subunit beta
Mycobacterium tuberculosis
0.130070797
1
Escherichia coli
LEVO
MADSRQSKTAASPSPSRPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRESAAERGDVNPVGGL
EEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTF
IINGTERVVVSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGWTSE
QIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLHVGE
PITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTT
QDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPI
ETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAG
EVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVAEE
SGVIEEVSADYITVMHDNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVAIMPW
EGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNISDEVLADLDERGIVRIGAEVRDGDILVGKV
TPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELVRVYVAQKRKISDGDKLA
GRHGNKGVIGKILPVEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDELLEA
QPNAIVSTPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYPVTVGYMYIMKLHHLVDDKIHARST
GPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLK
ELQSLCLNVEVLSSDGAAIELREGEDEDLERAAANLGINLSRNESASVEDLALARHGGS
V9Z879
2.7.7.6
DNA-directed RNA polymerase subunit beta'
Mycobacterium tuberculosis
0.148202219
1
Escherichia coli
LEVO
GAMLDVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERC
GVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVDEEMRHNELSTLEAEMAVE
RKAVEDQRDGELEARAQKLEADLAELEAEGAKADARRKVRDGGEREMRQIRDRAQRELDRLEDIWSTFTKLAPKQLIVDE
NLYRELVDRYGEYFTGAMGAESIQKLIENFDIDAEAESLRDVIRNGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVP
VIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRP
LKSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVER
QRPQVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARIL
MLSSNNILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQPASGDHPETGVYSSPAEAIMAADRGVLSVRAKIKVRLT
QLRPPVEIEAELFGHSGWQPGDAWMAETTLGRVMFNELLPLGYPFVNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKD
AGFYWATRSGVTVSMADVLVPPRKKEILDHYEERADKVEKQFQRGALNHDERNEALVEIWKEATDEVGQALREHYPDDNP
IITIVDSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSFREGLTVLEYFINTHGARKGLADTALRTADSGYLTRRLV
DVSQDVIVREHDCQTERGIVVELAERAPDGTLIRDPYIETSAYARTLGTDAVDEAGNVIVERGQDLGDPEIDALLAAGIT
QVKVRSVLTCATSTGVCATCYGRSMATGKLVDIGEAVGIVAAQSIGEPGTQLTMRTFHQGGVGEDITGGLPRVQELFEAR
VPRGKAPIADVTGRVRLEDGERFYKITIVPDDGGEEVVYDKISKRQRLRVFKHEDGSERVLSDGDHVEVGQQLMEGSADP
HEVLRVQGPREVQIHLVREVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGSLIDRAEFEAENRRVVAEGG
EPAAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAGTGINRYRNIAVQPTEEA
RAAAYTIPSYEDQYYSPDFGAATGAAVPLDDYGYSDYRHHHHHHHH
A5U053
2.7.7.6
DNA-directed RNA polymerase subunit omega
Mycobacterium tuberculosis
0.011776995999999998
1
Escherichia coli
LEVO
GSISQSDASLAAVPAVDQFDPSSGASGGYDTPLGITNPPIDELLDRVSSKYALVIYAAKRARQINDYYNQLGEGILEYVG
PLVEPGLQEKPLSIALREIHADLLEHTEGE
A0A0T9N9K3
2.7.7.6
RNA polymerase sigma factor SigA
Mycobacterium tuberculosis
0.058169477
1
Escherichia coli
LEVO
GPHMAATKASTATDEPVKRTATKSPAASASGAKTGAKRTAAKSASGSPPAKRATKPAARSVKPASAPQDTTTSTIPKRKT
RAAAKSAAAKAPSARGHATKPRAPKDAQHEAATDPEDALDSVEELDAEPDLDVEPGEDLDLDAADLNLDDLEDDVAPDAD
DDLDSGDDEDHEDLEAEAAVAPGQTADDDEEIAEPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGK
VALLNAEEEVELAKRIEAGLYATQLMTELSERGEKLPAAQRRDMMWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAF
LDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPE
ELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRL
RFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
P9WGI0
RNA polymerase-binding protein RbpA
Mycobacterium tuberculosis
0.012993695
1
Escherichia coli
LEVO
MADRVLRGSRLGAVSYETDRNHDLAPRQIARYRTDNGEEFEVPFADDAEIPGTWLCRNGMEGTLIEGDLPEPKKVKPPRT
HWDMLLERRSIEELEELLKERLELIRSRRRG
P9WHJ4
DNA (31-MER)
synthetic construct
0.009565193
1
(DG)(DC)(DT)(DT)(DG)(DA)(DC)(DA)(DA)(DA)(DA)(DG)(DT)(DG)(DT)(DT)(DA)(DA)(DA)(DT)
(DT)(DG)(DT)(DG)(DC)(DT)(DA)(DT)(DA)(DC)(DT)
DNA
DNA (26-MER)
synthetic construct
0.007930155
1
(DA)(DG)(DC)(DA)(DC)(DA)(DA)(DT)(DT)(DT)(DA)(DA)(DC)(DA)(DC)(DT)(DT)(DT)(DT)(DG)
(DT)(DC)(DA)(DA)(DG)(DC)
DNA
ZINC ION
6.5409e-05
2
ZN
MAGNESIUM ION
2.4305e-05
1
MG
methyl [(1E,5R)-5-{(3E)-3-[(2E,4E,8R,9E,12E)-1,8-dihydroxy-2,5,9-trimethyltetradeca-2,4,9,12-tetraen-1-ylidene]-2,4-dioxo-3,4-d ihydro-2H-pyran-6-yl}hex-1-en-1-yl]carbamate
0.0005276489999999999
1
C0L
singleParticle
particle
8.0
unspecified
ETHANE
FEI TITAN KRIOS
FLOOD BEAM
BRIGHT FIELD
FIELD EMISSION GUN
300
GATAN K2 SUMMIT (4k x 4k)
69.9
1
4.4
FSC 0.143 CUT-OFF
223000
ANGULAR RECONSTITUTION
PROJECTION MATCHING