2021-02-10RELPDBjPDBjPDBj2019-06-072019-08-282019-08-282021-02-10Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ATP state class3)Hiraizumi MYamashita KNishizawa TNureki OHiraizumi MYamashita KNishizawa TNureki OCryo-EM structures capture the transport cycle of the P4-ATPase flippase.ScienceUS36511491155201931416931doi:10.1126/science.aay33531095-92030038SCIEASEMD-9936associated EM volumeATP8A1-CDC50aATP8A1-CDC50a012Homo sapiensHomo sapienspcDNA3.4ATP8A1Homo sapiensHomo sapiensLEVOGSREFMPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVS
TAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIK
EIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVNVGDIVIIKGKEYIPADTVLLSSS
EPQAMCYIETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNI
RLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITN
VQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIILFNNLI
PISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLT
CNVMQFKKCTIAGVAYGQNSQFGDEKTFSDSSLLENLQNNHPTAPIICEFLTMMAVCHTA
VPERERDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFT
SARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAETSKYKEITLKHLEQFATEGLRTLCFA
VAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPET
IETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTRETLSRHCTTL
GDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKK
QVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMIHGAW
NYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGI
FERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTAFG
NGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWP
AIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVYKVIKRTAFKTLVDEVQELEAK
SQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESLQQNLLHGYAFSQDENGIVSQSEV
IRAYDTTKQRPDEWCDC50aHomo sapiensHomo sapiensLEVOMAMNYNAKDEVDGGPPCAPGGTAKTRRPDNTAFKQQRLPAWQPILTAGTVLPIFFIIGLI
FIPIGIGIFVTSNNIREIEIDYTGTEPSSPCNKCLSPDVTPCFCTINFTLEKSFEGNVFM
YYGLSNFYQNHRRYVKSRDDSQLNGDSSALLNPSKECEPYRRNEDKPIAPCGAIANSMFN
DTLELFLIGNDSYPIPIALKKKGIAWWTDKNVKFRNPPGGDNLEERFKGTTKPVNWLKPV
YMLDSDPDNNGFINEDFIVWMRTAALPTFRKLYRLIERKSDLHPTLPAGRYSLNVTYNYP
VHYFDGRKRMILSTISWMGGKNPFLGIAYIAVGSISFLLGVVLLVINHKYRNSSNTADIT
IsingleParticleparticle47.5ETHANEFEI TITAN KRIOSOTHERBRIGHT FIELDFIELD EMISSION GUN300GATAN K3 BIOQUANTUM (6k x 4k)64.013.32FSC 0.143 CUT-OFF146659MAXIMUM LIKELIHOODMAXIMUM LIKELIHOODemd_9936_msk_1.mapemd_9936_half_map_1.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
260
260260
0
00260260260215.8215.8215.890.090.090.0XYZ-0.0411155670.058890387-1.4398171e-050.00276753560.830.830.83emd_9936_half_map_2.map.gz1IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)